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200 ± 80 4466 ± 107 Although the iso-n-electronic heterocycles 1,2,5-oxadiazole and pyrazine have been shown to biologically mimic the 1,2,5-thiadiazole heterocycle, the 1,2,5- oxadiazole analog 26 of 12f had relatively poor muscarinic affinity and m1 efficacy compared to 12f (Table 2). 44 pgmL on Day 25; however, there was no correlation between decreases in VEGF levels and decline in M protein, percent plasma- cytosis, or extended cycles of therapy.
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