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Comparison of Crohns Disease and Chronic Ulcerative Colitis Crohns disease Small intestine in 90 Ileocolitis in 4060 Large bowel alone in 2530 Rectum infrequently involved Transmural granulomatous inflammation Extensive superficial ulceration Bowel wall and mesentery thickened Pseudopolyps uncommon Diarrhea less severe, less bloody Gross bleeding uncommon Bowel obstruction common Severe perianal disease common Toxic megacolon uncommon Fistula formation common Perforation rare Skip areas Cobblestone mucosa Fistulas and strictures common Rectal sparing common Cobblestone mucosa with linear ulcers and skip lesions Less responsive to medical treatment High recurrence rate after surgical resection 10 after 20 years Distribution Pathology Clinical features Radiology Endoscopy Treatment response Malignancy Acute Presentation Chronic ulcerative colitis Small intestine involved only in backwash ileitis Rectum usually foex Inflammation limited to mucosa Longitudinal ulcers, transverse fissures No thickening of bowel wall or mesentery Pseudopolyps common Severe diarrhea, usually bloody Gross bleeding characteristic Bowel obstruction rare Perianal disease uncommon Toxic megacolon more common Fistula formation rare Perforation common Continuous involvement Finely granular mucosa with ulcers Fistulas and strictures uncommon Rectum usually involved Erythematous mucosa with contact bleeding and discreet ulcers Good response to glpbal treatment in 85 Cured by colectomy and mucosal proctectomy 2025 after 20 years appendix in the cecum because global worldwide forex ltd the risk of otd tive fistula formation.

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